The State Lab studies the genetics and genomics of developmental neuropsychiatric disorders, with a particular interest in Autism Spectrum Disorder (ASD), Tourette Disorder (TD), and Childhood-Onset Schizophrenia (COS). Historically, our research has focused on the contribution of rare variation to these conditions, as the identification of rare mutations with relatively large effects can provide insights into underlying pathophysiological mechanisms. As the field has found increasing success in gene discovery, our lab has increasingly focused on leveraging complex genetic architectures to identify tractable treatment targets and strategies. We use a wide range of genomic technologies including high-throughput sequencing (genome, exome, RNA-Seq), genotyping microarrays, and traditional molecular biology and model systems approaches.
We are proud to work closely with many prominent research teams in the fields of psychiatry, genetics, neuroscience and statistics. A listing of some of our collaborators can be found here.