The State Lab studies the genetics and genomics of developmental neuropsychiatric disorders, with a particular interest in Autism Spectrum Disorder (ASD), Tourette Disorder (TD), and Childhood-Onset Schizophrenia (COS). Historically, our research has focused on the contribution of rare variation to these conditions, as the identification of rare mutations with relatively large effects can provide insights into underlying pathophysiological mechanisms. As the field has found increasing success in gene discovery, our lab has increasingly focused on leveraging complex genetic architectures to identify tractable treatment targets and strategies. We use a wide range of genomic technologies including high-throughput sequencing (genome, exome, RNA-Seq), genotyping microarrays, and traditional molecular biology and model systems approaches.
We have established a group of close collaborators, with whom we share mutiple projects, all aimed at translating gene discovery into an actionable understanding of biology. These colleagues include the Devlin Lab at UPMC, the Roeder Lab at Carnegie Mellon, the Sestan Lab, Noonan Lab, Gunel Lab, and Giraldez Lab at Yale, and the Sohal Lab and Rubenstein Lab at UCSF, among others.